lorlatinib will reduce the extent or impact of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Prevent use of lorlatinib with CYP3A substrates, wherever minimal focus alterations could lead to really serious therapeutic failures on the substrate.

In thoroughly selected sufferers, with thanks consideration of greatest dosage suggestions, administration from the drug at bedtime could be an acceptable limited-term preventive measure

saquinavir will increase the stage or impact of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

There won't be any studies on placental transfer or teratogenicity of The mixture of ergotamine and caffeine

fosamprenavir will boost the level or outcome of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

Monitor Closely (1)ergotamine will raise the stage or outcome of finerenone by influencing hepatic/intestinal enzyme CYP3A4 metabolism.

caffeine will reduce the level or effect of iobenguane I 131 by Other (see remark). Prevent or Use Alternate Drug. Based upon the mechanism of motion of iobenguane, medicines that reduce catecholamine uptake or that click here deplete catecholamine outlets may perhaps interfere with iobenguane uptake into cells, and thus, lessen iobenguane efficacy.

duvelisib will increase the degree or outcome of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration with duvelisib increases AUC of a sensitive CYP3A4 substrate which may boost the risk of toxicities of those medication.

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fosphenytoin will decrease the extent or influence of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

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mobocertinib will lower the level or impact of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. If use is unavoidable, raise CYP3A4 substrate dosage in accordance with its prescribing info.

Contraindicated (1)cobicistat will increase the degree or outcome of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.